GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
GUT365 Probiotic + Prebiotic Effervescent Tablets
Naturesque - Vitamins & Supplements

GUT365 Probiotic + Prebiotic Effervescent Tablets

20 Billion CFU. 6 Clinically Studied Strains. One daily fizz — for gut health you can actually feel.

GUT365 is Naturesque's most advanced gut health formula — a synbiotic (probiotic + prebiotic) effervescent tablet delivering 20 Billion CFU across 6 clinically studied bacterial strains. More strains, more CFU, and a fizzy Lemon delivery format that is 2x more bioavailable than traditional capsules. Drop. Dissolve. Drink. Done — every day, 365 days a year.

Gut Health + Digestive Balance + Immunity
Lemon — Natural Flavour
Reduces Bloating & Gas
Relieves Constipation & IBS
Sugar-Free · Gluten-Free · Vegetarian
ISO/GMP certified

GUT365 by Naturesque is a clinically formulated synbiotic effervescent tablet combining 20 Billion CFU from 6 clinically studied probiotic strains — Lactobacillus Acidophilus 4 Bn CFU (bloating + immunity), Lactobacillus Rhamnosus 4 Bn CFU (gut barrier + diarrhoea), Lactobacillus Casei 3 Bn CFU (bowel regularity + IBS), Bifidobacterium Lactis 3 Bn CFU (digestion + inflammation), Bifidobacterium Bifidum 3 Bn CFU (microbiome restoration), and Streptococcus Thermophilus 3 Bn CFU (gut inflammation) — paired with 300mg prebiotic blend from Chicory Root Extract / Inulin (200mg) and Apple Pomace Fibre (100mg). Other ingredients: Citric Acid, Sodium Bicarbonate, Malic Acid, Sodium Carbonate, Natural Lemon Flavour, Stevia (INS 960), Natural Colour (INS 133). Serving size: 1 tablet (3.1g). 21 tablets per tube. Sugar-free, gluten-free, 100% vegetarian.

The Science Behind GUT365

GUT365's 6 strains aren't chosen by trend — every one has peer-reviewed clinical evidence behind it.

2015 · Journal of Clinical Gastroenterology

L. Acidophilus + B. Lactis — double-blind RCT showed 40% reduction in bloating severity at 4 weeks vs placebo.

2023 · PubMed Central

Multi-strain Lactobacillus + Bifidobacterium — network meta-analysis of 39 IBS studies showed significant superiority over placebo for abdominal bloating reduction.

2024 · PubMed Central

Multi-strain probiotic review — 46% reduction in abdominal pain, 33% reduction in IBS-related diarrhoea, 32% reduction in constipation documented across clinical trials.

2024 · PubMed Central

Gut-Brain Axis review — Bifidobacterium and Lactobacillus strains shown to modulate serotonin, GABA, and dopamine pathways — supporting mood, cognitive clarity, and stress resilience.

Based on clinical studies of individual probiotic strains present in the GUT365 formula.

Drop one GUT365 tablet into 250ml of water and wait for it to fully dissolve. Sip on the refreshing Lemon drink daily. During the first week, take GUT365 20 minutes before a meal to allow the probiotic strains to establish in the gut without interference from food. From the second week onwards, take it after a meal. Take daily for at least 8 weeks for full gut microbiome rebalancing. One tube contains 21 tablets.
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Gluten-Free Tested & Certified

Gluten-Free Tested & Certified

Sugar-Free Naturally Sweetened Only

Sugar-Free Naturally Sweetened Only

Non-GMO No Genetically Modified Ingredients

Non-GMO No Genetically Modified Ingredients

Heavy Metal Free Tested Per Batch

Heavy Metal Free Tested Per Batch

100% Vegetarian No Animal-derived Ingredients

100% Vegetarian No Animal-derived Ingredients

GMP + ISO Certified Manufacturing Standard

GMP + ISO Certified Manufacturing Standard

Benefits of
GUT365 — What the Strains Deliver

Every benefit is rooted in the documented clinical action of the 6 probiotic strains and prebiotic combination — not generic wellness claims.

1. Promotes a Healthy, Diverse Gut Microbiome

GUT365's 8-strain formula introduces beneficial Lactobacillus and Bifidobacterium bacteria that directly compete with pathogenic microorganisms, restore microbial diversity, and rebalance the gut ecosystem — the foundation of all downstream digestive, immune, and metabolic health benefits.

2. Reduces Bloating & Gas

Clinical studies on L. acidophilus NCFM and B. lactis Bi-07 show statistically significant reduction in bloating severity at 4 weeks vs placebo. These strains reduce fermentation of undigested food in the colon — the primary cause of gas and uncomfortable bloating — by improving carbohydrate metabolism in the gut.

3. Relieves Constipation & Supports Regularity

L. Rhamnosus is clinically documented for improving bowel movement frequency and stool consistency. B. Bifidum restores good gut bacteria and alleviates constipation by improving intestinal transit time. The prebiotic fibre in GUT365 further feeds these bacteria, amplifying their bowel-regulating effect.

4. Provides IBS Symptom Relief

Multi-strain Bifidobacterium and Lactobacillus combinations show consistent efficacy in clinical IBS trials — reducing abdominal pain scores, improving bowel habit, and providing global symptom relief. GUT365's 8-strain formula addresses multiple IBS pathways simultaneously for more comprehensive relief than single-strain supplements.

5. Strengthens Gut Lining & Immunity

Probiotics strengthen the intestinal epithelial barrier — reducing gut permeability (leaky gut) that allows pathogens and toxins to enter the bloodstream. Streptococcus Thermophilus supports growth of good bacteria and reduces gut inflammation. 70% of the body's immune system is located in the gut — a healthier gut means stronger overall immunity.

6. Supports Mood, Energy & Mental Clarity

The gut produces over 90% of the body's serotonin — the neurotransmitter responsible for mood regulation. Research on Bifidobacterium and Lactobacillus strains shows they modulate GABA, serotonin, and dopamine pathways via the gut-brain axis — providing measurable improvements in mood, stress resilience, and cognitive clarity beyond digestive health.

Your Gut Is an Ecosystem.

A balanced gut microbiome plays an important role in digestion, nutrient absorption, immune function and overall wellbeing.

Prebiotic Fibre and Probiotic Blend

Science + Nature

Carefully selected ingredients that work together. It's a blend of Prebiotic Fibre and Probiotics.

Our foundation

Where Ancient Ayurveda Meets Modern Science.

10,000+

Trusted Customers Across India
Trusted for clinically formulated Ayurvedic supplements

GMP + ISO

Certified Manufacturing Facility
ISO + GMP certified facility — stringent quality at every step

ODOP

Certified Indian Brand
Make in India initiative — proud of our roots

100% Plant-Based & Non-GMO

Vegetarian · Heavy Metal Free · No Artificial Additives

Clinically Proven Results

What 8 Weeks of GUT365 Can Do

Based on clinical studies of the individual strains in the GUT365 formula — the same Lactobacillus and Bifidobacterium strains used globally in peer-reviewed gut health trials.

46%

Reduction in Abdominal Pain
Clinical data from Bifidobacterium + Lactobacillus strain studies

33%

Reduction in IBS-Related Diarrhoea
Multi-strain probiotic clinical trials

32%

Reduction in Constipation
Bowel regularity improvement in 8-week trials

8 Weeks

To Full Gut Benefit
Optimal microbiome rebalancing observed after 8 weeks of consistent use

6 Clinically Studied Strains + Prebiotic Fuel

Every strain is selected for a specific, documented role in gut health. Together they cover the full spectrum of digestive, immune, and metabolic support.

Acidophilus

Key Compound: Lactobacillus acidophilus

L. Casei

Key Compound: Lactobacillus casei

L. Rhamnosus

Key Compound: Lactobacillus rhamnosus

B. Lactis

Key Compound: Bifidobacterium lactis

B. Bifidum

Key Compound: Bifidobacterium bifidum

S. Thermophilus

Key Compound: Streptococcus thermophilus

Prebiotic Fibre

Key Compound: Chicory Root + Apple Pomace

Visible Benfits, Day After Day

Fuel your gut health journey with consistent care.

Prebiotics + Probiotics: The Perfect Gut Duo

Probiotics introduce beneficial bacteria into your gut, while prebiotics provide the nourishment these good bacteria need to thrive. Together, they help support a healthy gut environment, maintain bacterial balance, and promote overall digestive wellness—making them a powerful duo for everyday gut health.

How to Consume

Drop. Dissolve. Drink. Repeat.

The simplest daily gut health ritual — takes less than 60 seconds and tastes like a refreshing drink.

01
Drop

Drop 1 GUT365 tablet into a glass of 200ml water. Room temperature or cold — do not use hot water.

02
Wait & Dissolve

Wait for the tablet to fully dissolve and the fizz to settle — approximately 1–2 minutes. Stir gently if needed.

03
Drink

Enjoy your refreshing Lemon probiotic drink. Best consumed immediately after dissolving.

04
Daily — 365

Take every day without interruption. GUT365 is designed for year-round daily use — hence the name. Consistent daily intake builds the healthiest, most diverse gut microbiome.

Who This Is For

Struggling With Gut, Digestion or Energy?

GUT365 is for anyone experiencing digestive discomfort, immune weakness, or the low energy and mood that an imbalanced gut microbiome causes.

💨 Constant bloating, gas, and abdominal discomfort
Feeling heavy, uncomfortable, and bloated — especially after meals — affecting confidence and daily comfort.

✓ L. Acidophilus + B. Lactis reduce bloating — clinically proven at 4 weeks
Statistically significant reduction in bloating severity vs placebo in peer-reviewed trials. GUT365 addresses the root cause — microbial imbalance causing abnormal fermentation.

🔄 Irregular bowel movements — constipation or diarrhoea
Unpredictable digestion disrupts daily life, causes discomfort, and signals a disrupted gut microbiome.

✓ L. Rhamnosus + B. Bifidum restore bowel regularity
Clinical data shows 32% reduction in constipation and 33% reduction in IBS-related diarrhoea with multi-strain Lactobacillus and Bifidobacterium combinations.

🛡️ Frequent illness, low immunity, slow recovery
Getting sick repeatedly, slow to heal, or feeling like your immune system is underperforming.

✓ GUT365 strengthens the gut where 70% of immunity lives
A balanced gut microbiome directly activates and regulates immune response. GUT365's multi-strain formula rebuilds the gut immunity foundation from within.

😔 Low mood, anxiety, or brain fog with no clear cause
Feeling mentally flat, stressed, or foggy — not realising the gut-brain connection is likely the missing link.

✓ Gut microbiome restoration supports serotonin and GABA production
Bifidobacterium and Lactobacillus strains modulate gut-brain neurotransmitter pathways — addressing the gut root of mood, stress resilience, and mental clarity.

💊 Taking probiotic capsules that don't seem to work
Standard probiotic capsules often don't deliver enough viable bacteria to the gut — defeated by stomach acid before they reach the intestine.

✓ GUT365's effervescent delivery is 2× more bioavailable than capsules
Pre-dissolved bacteria in liquid form bypass the capsule dissolution step — delivering more live CFU to the intestine where they actually work.

🍽️ Post-antibiotic gut disruption or acidity after meals
Antibiotics wipe out both harmful and beneficial bacteria — leaving the gut microbiome depleted, vulnerable, and dysbiotic.

✓ GUT365 restores microbiome diversity post-antibiotic
L. Casei, L. Rhamnosus, and Bifidobacterium strains are specifically documented for post-antibiotic microbiome restoration — repopulating beneficial bacteria rapidly.

Know More — The Science of GUT365

The Gut-Brain Connection — Why Your Gut Is Your Second Brain

Most people think of gut health as just digestion. The science says something far more important.

What the Science Says

What GUT365 Does About It

Your gut produces 90% of your body's serotonin
Serotonin — the neurotransmitter that regulates mood, happiness, and sleep — is primarily produced in the gut, not the brain. An unhealthy gut microbiome directly suppresses serotonin production, contributing to low mood, anxiety, and poor sleep.

Restores the microbiome that produces your serotonin
Bifidobacterium and Lactobacillus strains in GUT365 have been documented to positively modulate GABA and serotonin production in the gut — providing mood, stress, and cognitive benefits that go far beyond digestion.

Gut bacteria communicate with your brain via the vagus nerve
The gut and brain are in constant bidirectional communication through the gut-brain axis. Imbalances in gut bacteria have been linked to mood disorders, cognitive fog, stress dysregulation, and even anxiety and depression in peer-reviewed research.

Strengthens the gut barrier that protects immune function
GUT365's multi-strain formula strengthens the intestinal epithelial barrier — reducing gut permeability, preventing pathogen translocation, and creating the healthy gut environment in which immune cells can function optimally.

70% of your immune system lives in your gut
The gut-associated lymphoid tissue (GALT) houses the majority of the body's immune cells. A balanced microbiome directly activates and regulates immune response — making gut health the foundation of whole-body immunity, not just digestion.

Prebiotic fuel ensures probiotics thrive long-term
Without prebiotics, probiotic bacteria struggle to colonise and multiply after ingestion. GUT365's prebiotic fibre provides the nutritional fuel that allows all 6 strains to establish, grow, and sustain their beneficial effects in the gut over time.

GUT365: "More than gut health. A daily investment in your digestion, your immunity, your mood, and your mind — 365 days a year."

Know More — GUT365 vs The Market

On every metric that determines whether a probiotic actually works — GUT365 leads.

Parameter

GUT365

Standard Probiotic (India)

Standard Capsule

Probiotic Strains

6 clinically studied strains

1–3 strains (typical)

1–3 strains (typical)

CFU per Dose

20 Billion CFU

18 Billion CFU

1–10 Billion CFU

Bioavailability

2× — pre-dissolved liquid delivery

Standard effervescent

Lower — capsule must dissolve in stomach acid

Prebiotic Included

Yes — feeds all 6 strains

Yes (some brands)

Rarely

Gut-Brain Axis Support

Yes — multi-strain mood + cognition

Partial

Rarely addressed

Daily Compliance

High — refreshing drink experience

Medium

Low — pill fatigue common

Sugar-Free

Yes

Not always

Usually yes

FAQs

What is GUT365 and how is it different from other probiotic supplements?

GUT365 is a synbiotic (probiotic + prebiotic) effervescent tablet delivering 20 Billion CFU across 6 clinically studied Lactobacillus and Bifidobacterium strains. It differs from standard probiotic supplements in three key ways: (1) More CFU — 20 Billion vs the 10–15 Billion typical of standard capsule probiotics, at the top of the clinically effective range, (2) Better delivery — effervescent format is 2× more bioavailable than standard capsules, as bacteria are pre-dissolved in liquid rather than trapped in a capsule that must survive stomach acid, and (3) Complete synbiotic — GUT365 combines probiotics AND prebiotics (Chicory Root + Apple Pomace) in every tablet, ensuring all 6 strains have the nutritional fuel to thrive in your gut.

When is the best time to take GUT365?

GUT365 is best taken after meals daily. Taking it after a meal means the stomach is in a less acidic state, which helps more of the 20 Billion CFU survive the journey to the intestine where they colonise and work. Drop one tablet into 200ml of water, let it fully dissolve, stir gently, and drink. Make it part of your post-meal routine for best daily compliance and results.

How long does it take to see results with GUT365?

Most users notice initial improvements in bloating, gas, and digestive comfort within 2–3 weeks of consistent daily use. Some users may notice changes in 24–48 hours as the gut microbiome responds to the new probiotic strains. Full gut microbiome rebalancing — including sustained IBS relief, immune strengthening, and mood/energy improvements via the gut-brain axis — is observed after 8 weeks of consistent daily use. The key is consistency — skipping days delays microbiome rebalancing.

Is it normal to feel more bloated when starting GUT365?

Yes — and this is a sign the product is working. When new probiotic strains are introduced into the gut, the existing microbiome undergoes adjustment. This can cause mild bloating, gas, or altered bowel habits in the first 3–7 days. This is a normal and temporary response — sometimes called a "die-off" response — and it typically resolves completely as the beneficial bacteria establish and the harmful bacteria are displaced. If symptoms are severe or persist beyond 2 weeks, consult a healthcare professional.

Can I take GUT365 after a course of antibiotics?

Yes — and post-antibiotic recovery is one of GUT365's most important use cases. Antibiotics eliminate both harmful and beneficial bacteria, leaving the gut microbiome depleted and vulnerable to dysbiosis and opportunistic infections. L. Casei, L. Rhamnosus, and Bifidobacterium strains in GUT365 are specifically documented for post-antibiotic microbiome restoration. For best results, begin taking GUT365 as soon as your antibiotic course ends, and continue for at least 8 weeks.

Can I take GUT365 every day long-term?

Yes — GUT365 is designed for daily year-round use, hence the name GUT365. The gut microbiome requires continuous nutritional support to maintain its diversity and balance. Stopping probiotics allows the gut environment to gradually return to its previous state. The most significant long-term benefits — stronger immunity, consistent digestive comfort, sustained mood and energy — are achieved through continuous daily use. GUT365 contains no stimulants, synthetic additives, or habit-forming compounds.

Is GUT365 suitable for vegetarians?

Yes. GUT365 is 100% vegetarian. All 6 probiotic strains are derived from plant-based fermentation processes. The effervescent tablet formulation contains no animal-derived ingredients, gelatin, or artificial additives — making it suitable for vegetarians and those on plant-based diets.

Why does GUT365 have 6 strains when some supplements have only 1?

Your gut microbiome contains hundreds of different bacterial species, each performing different functions. A single-strain probiotic addresses one function — a multi-strain formula addresses many simultaneously. Clinical research consistently shows that multi-strain Lactobacillus and Bifidobacterium combinations outperform single-strain formulas in IBS symptom relief, bloating reduction, and immune support. GUT365's 8-strain formula covers digestive health, immunity, bowel regularity, gut barrier integrity, and gut-brain axis support — a comprehensive scope no single-strain supplement can match.